Metabolic acidosis is a common consequence of advanced chronic renal failure (CRF) and maintenance dialysis (MD) therapies are not infrequently unable to completely correct the base deficit. Can correcting this chronic metabolic acidosis slow or prevent progressive kidney damage?
In fact, metabolic acidosis is noted in the majority of patients with chronic
kidney disease (CKD) when glomerular filtration rate (GFR) decreases to less
than 20% to 25% of normal, although as many as 20% of individuals can have
acid-base parameters close to or within the normal range.
In patients with chronic kidney disease, metabolic acidosis can occur as a
result of insufficient ammoniagenesis within the damaged kidney. This, in turn,
can bring about a variety of sequella that have their basis in hormonal and
cellular abnormalities that effect stunted growth, loss of muscle and bone mass,
and negative nitrogen balance.
In chronic kidney disease, metabolic acidosis occurs as a result of a lack of
sufficient ammoniagenesis within the damaged kidney and manifests itself in a
number of nonspecific clinical conditions including nausea, vomiting, fatigue,
anorexia, and exercise intolerance.
From the above we can see that metabolic acidosis in chronic renal failure
can greatly affect people’s health. So kidney disease patients that haven’t
developed into Uremia should actively prevent its happening.