2013年10月2日星期三
Kidney Disease Treatment : Nephrotic syndrome, several syndromes
Kidney Disease Treatment : Nephrotic syndrome, several syndromes: High blood pressure is a common complication of Nephrotic Syndrome. In return, it can exacerbate renal function.
FSGS cause and what are the basic symptoms
For those of you who are not familiar with focal segmental glomerulosclerosis (FSGS), it is a common cause of kidney failure found in both adults and children. During the earlier stages of this disease, FSGS is marked by proteinuria, and it has been discovered in both native and transplanted kidneys. Up until now, the cause of FSGS has not been fully understood, so the available treatments for FSGS have been limited. However with the support of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a team of researchers has made a recent discovery which could yield brand new treatments and help assess risk during transplantation.
What is FSGS?
Each person has two kidneys in their lower back. Each kidney is made up of approximately one million tiny filters called “glomeruli.” Much as a coffee filter keeps coffee grounds in, glomeruli keep valuable cells and protein in the blood. When glomeruli become damaged, proteins begin leaking into the urine (proteinuria). Proteinuria causes fluid to accumulate in the body, and prolonged leakage can lea d to kidney damage and even failure. Focal Segmental Glomerulosclerosis (FSGS) is a rare disease that attacks the kidney’s filtering system (glomeruli) causing serious scarring. FSGS is one of the causes of a serious condition known as Nephrotic Syndrome.
What causes glomerulosclerosis?
Glomerulosclerosis is not caused by a single disease. It has several different causes. The scarring may be the result of an infection, or drug toxicity, or a disease that affects the entire body, like diabetes, HIV infection, sickle cell disease or lupus disease. Sometimes, there is no apparent associated disease or cause. There may be a genetic component in some people.
Symptoms:
Some people with FSGS develop swelling (edema) of the eyelids in the morning and edema of the legs and body late in the day due to retention of fluid and this is what leads them to seek medical attention. Some notice foamy or bubbly urine when they urinate (due to the protein in the urine). Because symptoms may develop gradually, the disorder may first be discovered when there is an abnormal urine test (with protein and blood) or blood test (abnormal kidney function) done for a routine physical exam or on exam for an unrelated disorder. Many patients will have high blood pressure at the time of diagnosis.
All about FSGS, you can get a good answer kidney-support@hotmail.com this mailbox, you can always leave a message here, we will be in within 24 hours to give you a satisfactory answer.
What is FSGS?
Each person has two kidneys in their lower back. Each kidney is made up of approximately one million tiny filters called “glomeruli.” Much as a coffee filter keeps coffee grounds in, glomeruli keep valuable cells and protein in the blood. When glomeruli become damaged, proteins begin leaking into the urine (proteinuria). Proteinuria causes fluid to accumulate in the body, and prolonged leakage can lea d to kidney damage and even failure. Focal Segmental Glomerulosclerosis (FSGS) is a rare disease that attacks the kidney’s filtering system (glomeruli) causing serious scarring. FSGS is one of the causes of a serious condition known as Nephrotic Syndrome.
What causes glomerulosclerosis?
Glomerulosclerosis is not caused by a single disease. It has several different causes. The scarring may be the result of an infection, or drug toxicity, or a disease that affects the entire body, like diabetes, HIV infection, sickle cell disease or lupus disease. Sometimes, there is no apparent associated disease or cause. There may be a genetic component in some people.
Symptoms:
Some people with FSGS develop swelling (edema) of the eyelids in the morning and edema of the legs and body late in the day due to retention of fluid and this is what leads them to seek medical attention. Some notice foamy or bubbly urine when they urinate (due to the protein in the urine). Because symptoms may develop gradually, the disorder may first be discovered when there is an abnormal urine test (with protein and blood) or blood test (abnormal kidney function) done for a routine physical exam or on exam for an unrelated disorder. Many patients will have high blood pressure at the time of diagnosis.
All about FSGS, you can get a good answer kidney-support@hotmail.com this mailbox, you can always leave a message here, we will be in within 24 hours to give you a satisfactory answer.
Nephrotic syndrome, several syndromes
High blood pressure is a common complication of Nephrotic Syndrome. In return, it can exacerbate renal function. Therefore, it is very important for the patients with Nephrotic Syndrome to keep their blood pressure within the target level.
The kidney performs several vital functions in body. It can filter blood and discharge the excessive water by producing urine. In Nephrotic Syndrome, the permeability of the glomerular filtration membrane increases and can not filter blood normally as before. However, the renal tubule still keeps normally so they can reabsorb water and sodium thus arousing retention of water and sodium.
Therefore, the blood flow will increase thus resulting in high blood pressure.
Nephrotic syndrome from a medical point of view, is not a single disease, is characterized by massive proteinuria, severe edema, hyperlipidemia, and hypoalbuminemia. Without timely and effective treatment, can easily lead to other concurrent symptoms.
1. Infection: Nephrotic Syndrome may cause diplococcal pneumonitis, peritonitis or sepsis. As the patients often have protein malnutrition, low IgG level and complement protein level. Therefore, the white blood function decreases, which can cause the immunity to decline.
2. Acute Renal Failure: As the patients often lose a large amount of protein loss in urine, it can cause the albumin level in blood to decrease. Consequently, the plasma oncotic pressure decreases and the effective circulating blood volume decreases. As a result, the glomerular filtration rate decreases.
3. Thrombopoiesis :The activity of antithrombotic factors declines so the aggregation ability and glutinousness of blood rise. Moreover, low protein level and high fat level in blood can make blood become thick. Arteriosclerosis can damage wall of blood vessels, which can cause the blood hypercoagulable state. As a result, the patients often have renal vein embolism.
4. Malnutrition : As Nephrotic Syndrome often loss a large amount of protein in urine, it is very likely to cause protein malnutrition thus resulting in amyotrophy and development disorder for children. In addition, the lost proteins combine with microelements such as zinc, bronze and so on. Therefore, the patients with Nephrotic Syndrome often have hypozincemia, weak immunity, and anemia and so on.
5. Blood vessels diseases : Long term hyperlipidemia, especially low-density lipoprotein can lead to coronary thrombosis.
6. Abnormal renal tubule function : A large of proteins flow into proximal tubule, it can cause tubule disorder. The patients with Nephrotic Syndrome may have renal glucosuria, acidaminuria and proximal renal tubular acidosis.
The kidney performs several vital functions in body. It can filter blood and discharge the excessive water by producing urine. In Nephrotic Syndrome, the permeability of the glomerular filtration membrane increases and can not filter blood normally as before. However, the renal tubule still keeps normally so they can reabsorb water and sodium thus arousing retention of water and sodium.
Therefore, the blood flow will increase thus resulting in high blood pressure.
Nephrotic syndrome from a medical point of view, is not a single disease, is characterized by massive proteinuria, severe edema, hyperlipidemia, and hypoalbuminemia. Without timely and effective treatment, can easily lead to other concurrent symptoms.
1. Infection: Nephrotic Syndrome may cause diplococcal pneumonitis, peritonitis or sepsis. As the patients often have protein malnutrition, low IgG level and complement protein level. Therefore, the white blood function decreases, which can cause the immunity to decline.
2. Acute Renal Failure: As the patients often lose a large amount of protein loss in urine, it can cause the albumin level in blood to decrease. Consequently, the plasma oncotic pressure decreases and the effective circulating blood volume decreases. As a result, the glomerular filtration rate decreases.
3. Thrombopoiesis :The activity of antithrombotic factors declines so the aggregation ability and glutinousness of blood rise. Moreover, low protein level and high fat level in blood can make blood become thick. Arteriosclerosis can damage wall of blood vessels, which can cause the blood hypercoagulable state. As a result, the patients often have renal vein embolism.
4. Malnutrition : As Nephrotic Syndrome often loss a large amount of protein in urine, it is very likely to cause protein malnutrition thus resulting in amyotrophy and development disorder for children. In addition, the lost proteins combine with microelements such as zinc, bronze and so on. Therefore, the patients with Nephrotic Syndrome often have hypozincemia, weak immunity, and anemia and so on.
5. Blood vessels diseases : Long term hyperlipidemia, especially low-density lipoprotein can lead to coronary thrombosis.
6. Abnormal renal tubule function : A large of proteins flow into proximal tubule, it can cause tubule disorder. The patients with Nephrotic Syndrome may have renal glucosuria, acidaminuria and proximal renal tubular acidosis.
FSGS causes and related diagnostic methods introduced
Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury in the kidney that may have multiple different etiologies, including genetic diseases, infection, toxins and obesity, as well as previous injury resulting in hyperfiltration of remaining viable nephrons.
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What causes FSGS?
FSGS is “idiopathic,” which means it arises without a known cause, so researchers are actively trying to learn more.
How is FSGS diagnosed?
FSGS is diagnosed with renal biopsy (when doctors examine a tiny portion of the kidney tissue), however, because only some sections of the glomeruli are affected, the biopsy can sometimes be inconclusive.
What can I expect? Will treatment cure glomerulosclerosis?
Glomerulosclerosis is a chronic disease, because the scarred glomeruli cannot be repaired. Treatment can slow the progression of kidney disease. Everyone is different in how they respond to treatment, any complications, and the rate of disease progression. Over time, some patients with glomerulosclerosis gradually get worse until they reach kidney failure, If this occurs, they will need a kidney transplant or dialysis (hemodialysis or peritoneal dialysis) to stay alive. Some people respond well to treatment and may live with the disease for many years while being monitored for any signs of change.
All about all of FSGS, including treatment, you can get a good answer in kidney-support@hotmail.com inside the mailbox, you can always leave a message here, we will within 24 hours to give you a satisfactory answer.
FSGS is “idiopathic,” which means it arises without a known cause, so researchers are actively trying to learn more.
How is FSGS diagnosed?
FSGS is diagnosed with renal biopsy (when doctors examine a tiny portion of the kidney tissue), however, because only some sections of the glomeruli are affected, the biopsy can sometimes be inconclusive.
What can I expect? Will treatment cure glomerulosclerosis?
Glomerulosclerosis is a chronic disease, because the scarred glomeruli cannot be repaired. Treatment can slow the progression of kidney disease. Everyone is different in how they respond to treatment, any complications, and the rate of disease progression. Over time, some patients with glomerulosclerosis gradually get worse until they reach kidney failure, If this occurs, they will need a kidney transplant or dialysis (hemodialysis or peritoneal dialysis) to stay alive. Some people respond well to treatment and may live with the disease for many years while being monitored for any signs of change.
All about all of FSGS, including treatment, you can get a good answer in kidney-support@hotmail.com inside the mailbox, you can always leave a message here, we will within 24 hours to give you a satisfactory answer.
2013年10月1日星期二
Nephrotic syndrome associated with several manifestations and treatment
Nephrotic syndrome can not be seen as a single disease manifestations, but this group of diseases are characterized by very similar. Specifically, nephrotic syndrome are the following Performance.
1. Mass proteinuria
The patients with Nephrotic Syndrome can lose more than 3.5 grams protein in their urine. It is the main symptom of Nephrotic Syndrome.
2. Hypoproteinemia
Hypoproteinemia means that serum albumin is lower than 30 grams/L. It is caused by the mass loss of protein in urine.
3. Edema
Edema mainly occurs in the drooping parts of body. What’s worse, some patients have systemic edema, ascites, hydrothorax and even hydropericardium. Usually, the severity of edema varies with the severity of hypoproteinemia, but there are exceptive cases.
4. Hyperlipidaemia
The total serum, cholesterol, various kinds of lipoprotein and so on has obvious increasing.
Furthermore, in the event of nephrotic syndrome, kidneys can not process the body of water at this stage, this may cause too much of the fluid based on the body leading to edema.
To avoid the damage to the patients, they patients need to have diuretic therapy and water intake to reduce the accumulation of fluid in body. However, these can only be considered as assistant treatment methods. As the edema in Nephrotic Syndrome is associated with protein leakage, the patients should take treatment to repair the damaged glomeruli to stop protein leakage. Immunotherapy has a favorable effect in treating Nephrotic Syndrome.
1. Mass proteinuria
The patients with Nephrotic Syndrome can lose more than 3.5 grams protein in their urine. It is the main symptom of Nephrotic Syndrome.
2. Hypoproteinemia
Hypoproteinemia means that serum albumin is lower than 30 grams/L. It is caused by the mass loss of protein in urine.
3. Edema
Edema mainly occurs in the drooping parts of body. What’s worse, some patients have systemic edema, ascites, hydrothorax and even hydropericardium. Usually, the severity of edema varies with the severity of hypoproteinemia, but there are exceptive cases.
4. Hyperlipidaemia
The total serum, cholesterol, various kinds of lipoprotein and so on has obvious increasing.
Furthermore, in the event of nephrotic syndrome, kidneys can not process the body of water at this stage, this may cause too much of the fluid based on the body leading to edema.
To avoid the damage to the patients, they patients need to have diuretic therapy and water intake to reduce the accumulation of fluid in body. However, these can only be considered as assistant treatment methods. As the edema in Nephrotic Syndrome is associated with protein leakage, the patients should take treatment to repair the damaged glomeruli to stop protein leakage. Immunotherapy has a favorable effect in treating Nephrotic Syndrome.
Complications associated with nephrotic syndrome awareness
Kidneys are important organs in body. They can filter the metabolic wastes and extra water out of body and preserve what the body need in blood. However, in Nephrotic Syndrom, the kidneys leak protein, which normally stay in blood into urine. For the protein in urine, the patients will have a series of symptoms.
Complications of nephrotic syndrome are mainly the following aspects.
1. Infection. Because a large number of immune globulin in urine leak out. Will reduce the amount of plasma proteins, affect the formation of antibodies. Corticosteroids and cytotoxic drugs, will cause the entire body's immune system decline.
2. Coronary artery disease. Nephrotic syndrome may always have hyperlipidemia, and hypercoagulability. Therefore, patients with this disease more likely to get coronary artery disease. It is said that the incidence of myocardial infarction eight times higher than the average person.
3. Thrombosis. Easy to get blood clots in patients with nephrotic syndrome, especially membranous nephropathy. The incidence of this disease is 25-40%. Some causes thrombosis, such as edema, hyperlipidemia, Venostasis. More importantly, the viscosity increased blood concentration.
nephrotic syndrome and secondary nephrotic syndrome. Nephrotic syndrome is due to glomerular disease. In other words, the main pathological changes in the kidney. Secondary nephrotic syndrome caused by systemic diseases such as cancer, systemic lupus erythematosus, amyloidosis, and so on. So, after being diagnosed with nephrotic syndrome, they first have to find a specific reason for the disease, resulting in relative treatment time.
1. Infection. Because a large number of immune globulin in urine leak out. Will reduce the amount of plasma proteins, affect the formation of antibodies. Corticosteroids and cytotoxic drugs, will cause the entire body's immune system decline.
2. Coronary artery disease. Nephrotic syndrome may always have hyperlipidemia, and hypercoagulability. Therefore, patients with this disease more likely to get coronary artery disease. It is said that the incidence of myocardial infarction eight times higher than the average person.
3. Thrombosis. Easy to get blood clots in patients with nephrotic syndrome, especially membranous nephropathy. The incidence of this disease is 25-40%. Some causes thrombosis, such as edema, hyperlipidemia, Venostasis. More importantly, the viscosity increased blood concentration.
nephrotic syndrome and secondary nephrotic syndrome. Nephrotic syndrome is due to glomerular disease. In other words, the main pathological changes in the kidney. Secondary nephrotic syndrome caused by systemic diseases such as cancer, systemic lupus erythematosus, amyloidosis, and so on. So, after being diagnosed with nephrotic syndrome, they first have to find a specific reason for the disease, resulting in relative treatment time.
IGA nephropathy face the disease should take action
IgA Nephropathy often occurs among young people. It is a kind of kidney disorder. When viruses or bacteria intrude into human body, it can cause immune response, Mesangial proliferation, and IgA complexes deposition within mesangial area. Therefore, the function of filtering waste, excess water and electrolytes is hampered.Then Iga Nephropathy occurs. Micro-Chinese Medicine Osmotherapy has proven effective and convenient in IgA Nephropathy.
Most IgA Nephropathy patients have Edema with different levels.For IgA Nephropathy patients, once Proteinuria appears, blood vessels fail to absorb enough water and thus the rest water may permeates into tissues. As a result, patients appear to have Edema in face or legs, which indicates renal function injury meantime. All above is about the information of Edema in IgA Nephropathy patients. According the medical experts, patients are suggested to take physical examinations termly so as to keep fit.
Check urine and blood regularly.
Besides the measures above, patients with IgA Nephropathy should have blood and urine tests regularly, which can examine illness stage exactly. Once urine becomes red or darkened, patients with IgA Nephropathy should go to hospital and get urine routine. The reason for Proteinuria and Hematuria is that glomerular filtration membrane is damaged, so its permeability is increased. Thus, protein and red blood cells leaks out from glomeruli. Proteinuria and Hematuria is difficult to control, but they are easily induced by cold. Therefore, patients with IgA Nephropathy should keep an eye on cold.
Other blood tests done to aid in the diagnosis include CRP or ESR, complement levels, ANA, and LDH. Protein electrophoresis and immunoglobulin levels can show increased IgA in 50% of all patients.
Shijiazhuang Kidney Disease Hospital is the largest Kidney disease hospital in china at present. We use three methods mainly to treat kidney disease, and they are Micro-Chinese medicine Osmotherapy, stem cell transplant, and immunoadsorbent technics. We have more than twenty years working experiences in treating kidney diseases, countless kidney disease patients recovered very well through the treatment of our hospital. If you need any help, please send an email to kidney-support@hotmail.com. We will do our best to help you!
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