How Is the Prognosis of Mesangial Lupus Nephritis

Lupus Nephritis is the secondary kidney disorder of lupus. The World Health Organization divides Lupus Nephritis into six classes. Mesangial Lupus Nephritis belongs to the class Ⅱ. How is the prognosis of Mesangial Lupus Nephritis? Is it possible to develop into Chronic Renal Failure?

Mesangial Lupus Nephritis is accompanied by normal diagnostic findings or with a mild degree of proteinuria but typically absence of hypertension. Generally speaking, the patients with Mesangial Lupus Nephritis do not present many discomforts and the prognosis of the disease good. However, it does not mean the patients should neglect its treatment. If not controlled in time, it is very likely to develop into more serious kidney disease.

In Mesangial Lupus Nephritis, the light microscopy can show complexes deposit in mesangial area plus mesangial proliferation. If the immune complexes can not be cleared up completely, they will cause further inflammation in kidneys. However, the conventional hormone can only suppress the inflammation, but can not remove the immune complexes at all. Therefore, the disease is very likely to relapse. Every relapse is a great trauma to the kidneys.

To treat Mesangial Lupus Nephritis fundamentally and prevent it from developing into the next class, just relying on hormone can not receive the therapeutic goal at all. Facing the ineffectiveness of hormone, our hospital introduces the latest treatment of kidney disease---immunotherapy into the treatment of Mesangial Lupus Nephritis. It is a complete therapeutic system mainly including Micro-Chinese Medicine Osmotherapy, Immunotherapy, blood purification etc.

Immunotherapy aims at relieving the symptoms of the disease by suppressing the abnormal inflammation and correcting the abnormal immune system as well as the impaired renal functional cells. Therefore, it can stop Mesangial Lupus Nephritis from progressing into more severe kidney disease.

Learn More: What are New Guidelines for Lupus Nephritis

Pregnancy in Nephrotic Syndrome

Can the women with Nephrotic Syndrome get pregnant? Can pregnancy accelerate the deterioration of renal function? Is there danger to the mother and baby in pregnancy? The following article will reply these questions.
Generally speaking, the women with Nephrotic Syndrome can have successful pregnancy after they control their disease condition very well.
If Nephrotic Syndrome relapses frequently during pregnancy, the patients will have to use hormone or immunosuppressive agents. It will certainly cause fatal problems to the baby. Therefore, the premise for the women to get pregnant is to get a fundamental recovery of the disease. For the patients with serious high blood pressure and renal insufficiency, they should firstly lower their blood pressure and restore their impaired renal function.
Meanwhile, the women with Nephrotic Syndrome should consider the risk of pregnancy. In pregnancy, their kidneys have to discharge the metabolic products of their own and the babies. Therefore, the kidneys have to over work, which will certainly cause excess burden on their kidneys. In severe case, they may have premature birth and slow growth of the fetus.
If the women with Nephrotic Syndrome accord with the following requirement, they can consider pregnancy.
1. The illness condition keeps stable within the recent two years, no hematuria, proteinuria and the proteinuria is less than 0.5 grams per day.
2. Their renal function keeps normal.
3. No high blood pressure or frequent urinary tract infection.
4. The pathological type is mild like minimal change kidney disease, early stage of membranous nephropathy etc.
If the patients with Nephrotic Syndrome do not meet the above requirements, they should delay the pregnancy. In that case, they should take treatment to improve their renal function and relieve the symptoms. If the disease is controlled well, they will be able to have a healthy baby.

Learn More: Nephrotic Syndrome and Chinese Medicine

Why Nephrotic Syndrome Is Refractory

Nephrotic Syndrome is a refractory disease in clinic. Usually, after a period of hormone treatment, most of the patients can have some relief in clinical symptoms. However, once they reduce the hormone dosages or encounter infections, the disease will reoccur at once. Why Nephrotic Syndrome is so refractory? Is there an effective treatment for nephritic syndrome?

Immune dysfunction plays a major role in Nephrotic Syndrome. Our human body has a strong immune system including innate immune system and back-up system to keep us stay in a healthy and normal state. When foreign pathological substances invade into body, the antibodies are activated by the immune system to defeat them. However, in Nephrotic Syndrome, the patient's innate immune system can not function normally. As a result, the innate immune system to send excess message to activate back-up immune system resulting in hypersensitive immune reaction. The reaction can cause inflammation of kidneys thus leading to kidney damage.
The conventional hormone therapy can suppress the inflammation of kidneys temporarily. However, the immune complexes which cause inflammatory injury of kidneys still exist in kidneys and the patients'innate immune system is not corrected yet. Therefore, once the patients reduce hormone dosage or encounter other inducing factors, the immune inflammation will reoccur again. That is why Nephrotic Syndrome is so refractory.

To treat Nephrotic Syndrome effectively and avoid its relapse, it is essential to clear up the immune complexes and correct the abnormal innate immune system. Here immunotherapy is recommended to the patients with Nephrotic Syndrome.
Immunotherapy aims at treating Nephrotic Syndrome from its underlying causes. On one hand, it can degrade the immune complexes and make them dissolve in blood. Afterwards, they will be discharged out of body through urination. On the other hand, it can help rebuild the innate immune system so as to avoid relapse of Nephrotic Syndrome fundamentally.

Although Nephrotic Syndrome is a refractory kidney disease, it is possible for the patients to receive a good recovery and get rid of relapse. In this way, they will be able to prevent aggravation of renal function effectively.

Learn More: TCM Combining with Western Medicines Treats Refractory Nephrotic Syndrome

Renal Fibrosis in Chronic Nephritis

Renal fibrosis is a kind of pathological changing process, in which the kidneys are damaged gradually until the kidneys fail completely. Renal fibrosis is an important cause in causing Chronic Nephritis progression.

In Chronic Nephritis, various causes cause renal injury and releasing of inflammatory factors resulting in inflammatory response and enhanced cellar activity. As the renal functional cells get more damage, the cells begin to have phenotypic transformation and ossify and lose function gradually. This is the early stage of renal fibrosis, in which more than half of the renal function still keeps normal so the patients do not present obvious symptoms yet. If the renal fibrosis process is not inhibited effectively, the renal function will keep declining further. When the renal fibrosis approaches to the middle stage, the levels of creatinine, BUN etc will rise obviously. With the progression of renal fibrosis, more and more nephrons lose their normal function. When the residual nephrons are less than 15%, the disease develops into End Stage Renal Failure, namely Uremia. In this stage, nearly all nephrons are ossified. In clinic, the patients will have a series of serious complications like brain disease, heart disease, systemic poisoning symptoms etc.

From the above we can see that if the Chronic Nephritis can not be controlled effectively in its early stage, it will activate the renal fibrosis. Further more, if the renal fibrosis can not be blocked, it will cause the renal function to decline gradually. The key to prevent Renal Failure is to block renal fibrosis.

As the inflammatory response is the primary cause of renal fibrosis, the patients should firstly take relevant treatment to prevent the releasing of the inflammatory factors. In this way, they will be able to prevent Chronic Nephritis from developing into Renal Failure.
If you or your loved one is Chronic Nephritis suffer and want to know other aspects on Chronic Nephritis, you can consult us on line or leave a message blow.

Learn More: What Is The Efficient Treatment for Chronic Nephritis in China

Can Patients with Nephrotic Syndrome Be Cured

Nephrotic Syndrome is a common disease in both adults and children. The prognosis varies with the individual conditions. According to the pathological categories of Nephrotic Syndrome, the minimal change glomerulonephritis usually have a good prognosis. However, the other pathological categories like FSGS, membranous glomerulonephritis may progress into Renal Failure in several years.

In fact, in the early stage of Nephrotic Syndrome, if it is treated properly, the patients have 50% chance to be cured permanently. However, in some cases, Nephrotic Syndrome relapses frequently and finally progresses into Renal Failure. That is because most of the patients do not attach much importance to the disease. In the early stage of Nephrotic Syndrome, most of the patients do not have much discomfort. Also after a period of hormone therapy, most of them have improvement obviously. At that time, they may think they are cured so they reduce hormone dosage without the doctors’ instruction. Unfortunately, it is very likely to cause the relapse of Nephrotic Syndrome. (How to Prevent The Relapse of Nephrotic Syndrome in Children )

In some cases, a child may be diagnosed with Nephrotic Syndrome at 2 or 3 years old and develop Renal Failure in his/her 20s. During such a long period, the disease may relapse again and again resulting in the worse result finally. Therefore, if Nephrotic Syndrome relapses frequently, the patients should have other alternative treatment at once to delay the development of the disease so as to get the opportunity of cure.

If the disease keeps progressively, it will cause damage more and more nephrons. Once the glomeruli are impaired extensively, it is very hard to reverse their renal function and the cure chance is very slight.

Therefore, to increase the chance of cure, the patients with Nephrotic Syndrome should have proper treatment as early as possible. If the hormone does not have effect at all or the disease relapses frequently after hormone therapy, they should choose other alternative treatment immediately.

Learn More: Nephrotic Syndrome and Chinese Medicine

Alternative Treatment for Lupus Nephritis Other Than Steroid

Steroid is commonly applied in the treatment of Lupus Nephritis. In the western medicine, steroid plays an irreplaceable role in the treatment of Kidney Disease and its effectiveness also has been proved by clinical practices. However, the enormous side effect of steroid is still a troublesome problem for the patients with Lupus Nephritis. If the patients keep long-term application of steroid, it will cause hair loss, obesity, and slow growth for the children etc. Therefore, depending on steroid alone can not bring a perfect therapeutic effect to the patients with Lupus Nephritis at all.

Facing the huge side effects of steroid, the medical experts begin to search for a better treatment of Lupus Nephritis other than steroid. After many years’ researches, they make an innovation in traditional Chinese medicine and introduce Micro-Chinese Medicine Osmotherapy into field of Kidney Disease treatment. Micro-Chinese Medicine Osmotherapy absorbs the advantages of traditional Chinese medicine fully, free of side effects, treating disease from its underlying causes other than symptoms etc.

The conventional steroid therapy only focuses the treatment of symptoms of Lupus Nephritis mainly proteinuria. Micro-Chinese Medicine Osmotherapy aims at relieving symptoms by eliminating its underlying cause. In Lupus Nephritis, the inflammation due to immune complexes causes damage to the glomerular epithelial cells thus resulting in clinical symptoms. In the treatment of Lupus Nephritis, Micro-Chinese Medicine Osmotherapy can clear up the immune complexes and prevent the relapsing of inflammatory factors. Therefore, it can block the inflammatory injury to the epithelial cells effectively its curative effects like dilating blood vessels, anti-inflammation, anticoagulation and preventing blood viscosity. Moreover, Micro-Chinese Medicine Osmotherapy can provide some nutrients which can promote the self-repairing of the impaired epithelial cells. In this way, the kidneys will be repaired very well. Afterwards, the clinical symptoms related to Lupus Nephritis will disappear naturally.

After reading the above article, if you still have questions about the therapy or your disease, you can consult us on line or leave a message below. Our expert will analyze your disease condition and give you a reply as soon as possible.

Learn More: What Is The Treatment for Lupus Nephritis in China

Symptoms of Stage 4 Chronic Kidney Disease

Glomerular filtration rate (GFR) is the best measure of kidney function. According to GFR, Chronic Kidney Disease is divided into 5 stages. In stage 4 Chronic Kidney Disease, the kidneys are damaged severely with a severe decrease in GFR to 15~30 ml/min. In stage 4 Chronic Kidney Disease, the patients mainly present the following symptoms.

Fatigue: In stage 4 Chronic Kidney Disease, most of the patients often have fatigue due to anemia. For nausea, vomiting and poor appetite, the patients can not get sufficient raw material of blood. Moreover, less hemopoietin is produced by kidneys, which is the leading cause of anemia.

Severe swelling: The kidneys may lose their ability to control how much fluid stay s in the body. The patients may have swelling in heir lower legs, hands or face around the eyes. In some cases, some patients may have pulmonary edema which can cause them feel short of breath.

Urination changes: In stage 4 Chronic Kidney Disease, urine may be foamy if there is protein in it. Also if the urine contains red blood cells, the urine will be tea colored or brown. A person may urinate more or less than normal, or have urination frequently at night.

Kidney pain: Most of the patients with stage 4 Chronic Kidney Disease do not have back pain. However, if the patients have cystic disease like Polycystic Kidney Disease, or infections, they may have pain in the kidney area.

Poor appetite: In stage 4 of Chronic Kidney Disease, some patients may be accompanied with gastrointestinal diseases and peptic ulcer disease. Moreover, the patients often have metallic taste in their mouth. These problems can affect the patients’ appetite and cause nausea, vomiting etc.

Sleep problem: Sleep problem is a lasting torment for the patients with stage 4 Chronic Kidney Disease. They may have trouble in falling asleep or staying asleep. Skin itching, muscle cramps or restless legs can keep them awake the whole night.

If you have one or several symptoms mentioned about and do not if they are related to kidney problems, you can consult us on line. Our experts will analyze your disease condition carefully and give you a reply as early as possible.

Learn More: How to Slow the Progression of Stage 4 of Chronic Kidney Disease